Thrift Drug was a pharmacy chain based in Pittsburgh, Pennsylvania that was founded in 1937 and purchased by J.C. Penney in 1968, and was expanded greatly thereafter. The chain served as the flagship chain of J.C. Penney's pharmacy group. The chain didn't hide its affiliation with J.C. Penney, as it had J.C. Penney catalogs inside their locations as well as signs advertising "J.C. Penney Catalog Center". Stores also accepted the J.C. Penney credit card for purchases.
In 1996, J.C. Penney purchased the Eckerd Pharmacy, and decided to merge Thrift Drug and all other pharmacy chains into the larger Eckerd chain (now Rite Aid). The Thrift Drug banner was retired by 1997.