He made his Villa debut in a 3–0 home defeat to Liverpool on 13 January 2001; it was his only appearance during his first season in England. Whilst at Aston Villa, Hitzlsperger was briefly loaned out to Chesterfield during the 2001–02 season, making his debut against Kidderminster Harriers in the LDV Vans Trophy. In all he made six appearances for the Spireites, five of which were in the league. He was recalled by Aston Villa during the second month of the loan spell however, as the Midlands club had several players injured or suspended. Hitzlsperger moved into the Aston Villa first team following the arrival of new manager Graham Taylor. He would go on to play a significant part in the Aston Villa side that would finish 6th under David O'Leary, before falling out of favour the following season. He left Aston Villa as a fan favourite, and stated that he might return to the club when the opportunity comes. Hitzlsperger gained the nickname 'der Hammer' ('the hammer') during his time at Villa Park, due to his powerful left-foot shot from long-range. A fluent speaker of English, he acquired an unusual Birmingham/German hybrid accent during his spell at Villa.
|- |2002-03||rowspan="3"|Aston Villa||rowspan="3"|Premier League||26||2|||||||||||||||| |- |2003-04||32||3|||||||||||||||| |- |2004-05||28||3|||||||||||||||| |- |2005-06||rowspan="4"|Stuttgart||rowspan="4"|Bundesliga||26||2|||||||||||||||| |- |2006-07||30||7|||||||||||||||| |- |2007-08||25||5|||||||||||||||| |- |2008-09||7||1||1||0||||||1||0||9||186||8||||||||||||||||88||15||||||||||||||||174||23|||||||||||||||| |}
Germany's coach Joachim Löw included Hitzlsperger in his squad for the finals of Euro 2008, but did not start him in any of the three group games. Hitzlsperger came on as a second-half substitute in the victories over Poland and Austria, and did not feature at all in the defeat to Croatia. In the knockout stages however, he started all three matches, helping his team to overcome Portugal in the quarter-finals and setting up Philipp Lahm for a 90th minute winner against Turkey in the semi. Germany were defeated 1–0 by Spain in the final, in which Hitzlsperger was substituted in the second half.
|1.||September 6, 2006||Stadio Olimpico, Serravalle, San Marino||9-0||13-0||UEFA Euro 2008 qualifying|
|2.||September 6, 2006||Stadio Olimpico, Serravalle, San Marino||11-0||13-0||UEFA Euro 2008 qualifying|
|3.||June 6, 2007||AOL Arena, Hamburg, Germany||2-1||2-1||UEFA Euro 2008 qualifying|
|4.||November 17, 2007||Allianz Arena, Munich, Germany||4-0||4-0||UEFA Euro 2008 qualifying|
|5.||February 6, 2008||Ernst-Happel-Stadion, Vienna, Austria||1-0||3-0||Friendly|
|6.||September 6, 2008||Rheinpark Stadion, Vaduz, Liechtenstein||5-0||6-0||FIFA World Cup 2010 qualifying|
Hitzlsperger has blogged for Störungsmelder, a site that encourages debate about xenophobia and racism in Germany.
In June 2007, Hitzlsperger split from his long-term girlfriend Inga, just one month before they were due to get married.