Three TRs exist in animals: TR1, TR3, and TGR. Both TR1 and TR3 are essential proteins for mouse embryogenesis.
For example, motexafin gadolinium (MGd) is a new chemotherapeutic agent that selectively targets tumor cells, leading to cell death and apoptosis via inhibition of thioredoxin reductase and ribonucleotide reductase.
Thioredoxin reductase activity in rat liver is not affected by supranutritional levels of monomethylated selenium in vivo and is inhibitied only by high levels of selenium...
Feb 01, 2001; Thioredoxin Reductase Activity in Rat Liver Is Not Affected by Supranutritional Levels of Monomethylated Selenium In Vivo and Is...
Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element1-3
Sep 01, 2003; ABSTRACT We previously reported the in vitro and in vivo induction of thioredoxin reductase (TR) by sulforaphane (SF) purified...