Thiamine triphosphatase


In enzymology, a thiamine-triphosphatase is an enzyme that catalyzes the chemical reaction

thiamine triphosphate + H2O rightleftharpoons thiamine diphosphate + phosphate

Thus, the two substrates of this enzyme are thiamine triphosphate and H2O, whereas its two products are thiamine diphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is thiamine-triphosphate phosphohydrolase. This enzyme participates in thiamine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .


  • Hashitani Y, Cooper JR "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 2117–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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