Maprotiline (trade named Ludiomil), and Mirtazapine (trade named Remeron in the USA, Remergil, Remeron and Zispin in Europe, and Avanza in Australia) are the only two drugs from this group widely used for the treatment of clinical depression. The tetracyclic antidepressant Mianserin was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.
Research on other tetracyclic antidepressant compounds (for example setiptiline) have been reported in the scientific literature. These other tetracyclic antidepressants are not publicly available.
|Adrenergic uptake inhibitor||Adrenergic alpha-antagonist||Dopamine antagonist||Serotonin uptake inhibitor||Serotonin antagonist||Histamine H1 antagonist|
Steady-State Concentrations of Mirtazapine, N-Desmethylmirtazapine, 8-Hydroxymirtazapine and their Enantiomers in Relation to Cytochrome P450 2D6 Genotype, Age and Smoking Behaviour
Jan 01, 2009; Abstract Background and objective: Mirtazapine is a tetracyclic antidepressant drug available as a racemic mixture of S and...