Music

• The Beatles, a British band.
• The Beatles (album), the tenth album by the above band, also known as the White Album.
• The Block, an album by boy band New Kids on the Block.

Science and medicine

• Terbium (chemical symbol Tb), a chemical element
• Tuberculosis, a chronic infectious disease

Technology

• .tb — Tab file (Virtual Desktop Tab)
• Terabit (Tb), a unit of information used, for example, to quantify computer memory or storage capacity
• Terabyte (TB), a unit of information used, for example, to quantify computer memory or storage capacity
• Text speak meaning "Text back"

Other

• Taco Bell (TB), a Mexican-style quick service restaurant chain.
• Tailback (TB), a position in American football.
• Tampa Bay (TB), a region in Florida.
• Tampa Bay Buccaneers (TB), a professional football team in the Tampa Bay Area.
• Tampa Bay Lightning (TB), a professional hockey team in the Tampa Bay Area.
• Tampa Bay Rays (TB), a professional baseball team in the Tampa Bay Area.
• Tampa Bay Storm (TB), a professional arena football team in the Tampa Bay Area.
• Teen Baby (TB), a teen that wishes to be a baby; also infantalism
• Total bases (TB), a baseball statistic.
• Treasury Bills (TB), are government bonds issued by the United States Department of the Treasury.