A film adaptation of Talk Radio, directed by Oliver Stone, was released in 1988.
A production was staged at the Edinburgh Fringe Festival in 2006. Directed by the comedian Stewart Lee & featuring the talents of Mike McShane, Phil Nichol, Stephen K Amos and others.
Talk Radio made its Broadway premiere on March 11, 2007, in a production starring Liev Schreiber, and featuring Law & Order: SVU stars Stephanie March and Peter Hermann, and The Covenant's Sebastian Stan. The opening night cast also included Christine Pedi, Barbara Rosenblat, Adam Seitz, Marc Thompson, Kit Williamson, Cornell Womack and Christy Pusz. The show was directed by Tony Award-winner Robert Falls, and has received Tony, Drama Desk, Outer Critics Circle, and Drama League award nominations for Best Revival of Play and Best Actor in a Play. Additionally, Schreiber was awarded the prestigious Drama League Award for Distinguished Performance. The show made its final Broadway performance at the Longacre Theater (220 West 48th Street) on June 24, 2007.
In Israel, on December 2007 Talk Radio ('Sikhot Layla') is premiered by Gesher Theather.