Tadjourah is a region in Djibouti. The district borders Ethiopia and Eritrea to the north/north-west, Obock Region to the north-east, Dikhil and Arta regions to the south and the Gulf of Tadjourah to the south-east. Lake Asal is located in the south of the district.

The capital of Tadjourah Region is Tadjourah. Other major cities and towns include Randa, Dorra and Balha.