2C-T-13 or 2,5-dimethoxy-4-(β-methoxyethylthio)phenethylamine is a psychedelic phenethylamine of the 2C family. It was presumably first synthesized by Alexander Shulgin and reported in his book PiHKAL (Phenethylamines i Have Known And Loved).
2C-T-13 is the 2 carbon homologue of Aleph-13. The full chemical name is 2-[4-(2-methoxyethylthio)-2,5-dimethoxyphenyl]ethanamine. The drug has structural properties similar to mescaline and other drugs in the 2C-T series, with the most closely related compounds being 2C-T-7 and 2C-T-21.
The dosage range of 2C-T-13 is typically 25 - 40 mg and its duration is approximately 6-8 hours according to Shulgin. 2C-T-13 produces many closed-eye visuals and geometric patterns. It also produces slight visual distortion.
The mechanism that produces 2C-T-13’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
The toxicity of 2C-T-13 is not well documented. 2C-T-13 is slightly less potent than 2C-T-7, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as 2C-T-7 and 4-MTA are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome when they are combined with stimulant drugs. Most confirmed fatalities involving 2C-T drugs involve their combination with other hard drugs such as alcohol, ecstasy or cocaine.