Sympathetic neuron

Non-noradrenergic, non-cholinergic transmitter

A non-noradrenergic, non-cholinergic transmitter (NANC) is a neurotransmitter of the peripheral nervous system (PNS) that is neither of the main two PNS transmitters, i.e. noradrenaline and acetylcholine.

Comparison table

This table compares different NANCs in the PNS:

Neurotransmitter Type Location Function
ATP non-peptide postganglionic sympathetic neurons (e.g. in blood vessels & vas deferens) Fast depolarization/contraction (vasoconstriction)
GABA non-peptide ENSs peristalsis
5-HT non-peptide ENSs peristalsis
dopamine non-peptide some SNSs (e.g. kidney) vasodilation
NO non-peptide pelvic nerves & gastric nerves

NPY peptide postganglionic sympathetic neurons (e.g. blood vessels
  • enhance vasoconstrictor action of noradrenaline
  • noradrenaline release inhibitor

VIP peptide

  • parasympathetic nerves to salivary glands
  • NANC innervation to smooth muscle of airways
  • vasodilation
  • acetylcholine cotransmitter
  • bronchodilation
  • GnRH peptide sympathetic ganglia

    • slow depolarization
    • acetylcholine cotransmitter

    substance P peptide

  • slow depolarization
  • acetylcholine cotransmitter
  • CGRP peptide non-myelinated sensory neurons


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