Upon entering Weatherfield, Frankie appeared stuck up and prissy, eager for Danny to sell the house they shared in London so they could move into somewhere more suitable. Frankie exploded when she discovered Danny had slept with Sunita Parekh, and declared war on her. This perhaps is what drew her to Sunita's nemesis Maya. However, after learning of Maya's true nature, she apologised to Sunita and forgave her.
After a while, Frankie began to settle into the street more - especially after striking up a bond with Vera Duckworth. When Vera was ill, Frankie took care of her by doing her chores for her, filling in her job for her and advised her husband Jack to be more sensitive and attentive to Vera's needs. This led to Frankie securing a permanent position at the cafe, where she works with enemy Leanne.
Frankie saw Leanne as not worthy for Jamie, and became suspicious of her cheating on him. Frankie discovered the affair by finding Leanne's phone and, going on her suspicions, read her text messages and listened to her voice messages - all from Danny. To add insult to injury, Danny called the phone and said all the things he wanted to do to Leanne - except Frankie was on the other end. Frankie chucked Danny out. She lived with Jamie, and Jamie's mother Carol. But after Carol accused Frankie and Jamie of sleeping with each other, Frankie kicked Carol out, and Carol left the street for good.
Danny, regretting losing her and scared at the thought of spending the rest of his life with Leanne, begged Frankie to take him back. Frankie remained strong and the divorce went ahead, with Frankie moving boyfriend Nathan in just days before. She celebrated her divorce by jetting off alone for a holiday in her newly accuired Villa in Spain.
In October 2006 Frankie's former stepson Jamie declared his love for her at Fred Elliott's funeral and they kissed but the revelation shocked her and drove her back into the arms of ex-husband Danny.
However she couldn't resist Jamie's advances and they embarked on a relationship, much to the disgust of the other residents of the street. The news also led to Danny disappearing.
Frankie and Jamie decided to head to Spain to start afresh, but at the last minute on New Year's Eve 2006, Frankie got cold feet. She ended it with a devastated Jamie, and left to stay with a friend in Essex. As she departed in a taxi, Jamie was consoled by friend Sean Tully. But the misery wasn't over - at midnight Jamie received a call from father, Danny, telling him he had sold the flat and he was "sorry" to hear about his break up with Frankie.