Epperson co-founded Salem Communications in 1972 with his brother-in-law, Edward G. Atsinger III. Through his involvement in that entity, he is a member of the board of directors of the National Religious Broadcasters Association. Time Magazine has named him one of the 25 most influential evangelicals in America.
Epperson lives in Winston-Salem, North Carolina. His wife, Nancy, is on the Board of international Christian broadcaster Trans World Radio (TWR). He has four children, daughters Kristy, Karen, and Kathy, and son Stuart Jr. A son-in-law, Will McBride (Kristy) was a candidate in the 2006 United States Senate election in Florida but lost by a substantial margin.