Steroid 17alpha-monooxygenase

a steroid + AH₂ + O₂ $rightleftharpoons$ a 17alpha-hydroxysteroid + A + H₂O

The 3 substrates of this enzyme are steroid, AH2, and O₂, whereas its 3 products are 17alpha-hydroxysteroid, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating). Other names in common use include steroid 17alpha-hydroxylase, cytochrome P-45017alpha, cytochrome P-450 (P-45017alpha,lyase), and 17alpha-hydroxylase-C17,20 lyase. This enzyme participates in c21-steroid hormone metabolism. It has 3 cofactors: NADH, NADPH, and Heme.

References

• LYNN WS Jr, BROWN RH "The conversion of progesterone to androgens by testes". J. Biol. Chem. 232 1015–30.
• Yoshida KI, Oshima H, Troen P "Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17 alpha-hydroxylation". J. Clin. Endocrinol. Metab. 50 895–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes