Steroid 11-beta-hydroxylase

Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona fasciculata.

Cytochrome P450, family 11, subfamily B, polypeptide 1, also known as CYP11B1, is a human gene.

Function

It generates cortisol from 11-deoxycortisol and corticosterone from 11-deoxycorticosterone. Note the extra "–OH" added at the 11 position (near the center, on ring "C"):

Clinical significance

A mutation is associated with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.

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