is a genus
of the retroviridae family
. Spumaviruses are exogenous
viruses that have specific morphology
with prominent surface spikes
. The virions
contain significant amounts of double-stranded full-length DNA
, and assembly is rather unusual in these viruses. Normally, the envelope
membrane is acquired by budding
through the endoplasmic reticulum
. However, in, for example, the equine foamy virus (EFV), budding from the cytoplasmic membrane
Some examples of this virus are the chimpanzee foamy virus, simian foamy virus and the human foamy virus.
While spumaviruses will form characteristic large vacuoles in their host cells while in vitro, there is no disease association in vivo.
- Santillana-Hayat M, Valla J et al. "Inhibition of the in vitro infectivity and cytopathic effect of human foamy virus by dideoxynucleosides". AIDS Res Hum Retroviruses. 1996 Oct 10; 12(15):1485-90.