US Highway 60 cuts through Spottsville. The Green River runs through Spottsville, and the Green River Lock & Dam is located in the city. If you travel east through Spottsville, you can see the Lock to your right when you cross the Green River bridge. You can still see some of the remains of the old locks that were replaced in the mid 1960's; to your left, you can see a turning bridge for trains (it turns when a barge comes through).
There is one store in Spottsville, and two churches (most Spottsville church goers attend outside of the city), and one school, which serves all of the Eastern part of Henderson County (including Beals, Baskett, and Reed). Spottsville school provided Henderson County's first school bus service in 1920. The first Spottsville school burned down in March of 1932.
Spottsville was named for Colonel Spotts. The area was visited by the Spanish explorer, Hernando de Soto, in 1541. His army was attacked near the Ohio River by Indians of a tribe or tribes called variously the Kashinampo, the Quizqui, and the Chiska.