The museum is believed to have been established around 1925, based on the history of Spode pottery from the time of Josiah Spode (1733–1797) to the present. The museum became a charitable trust in 1987.
In 1996, a new museum was created within the Spode Visitor Centre. It is open free of charge to the public. The collection displays many wares by Josiah Spode I and II, including underglaze blue printing and the invention of bone china, two of the most important developments that they achieved.