is a special form of RNA processing
from two different primary RNA transcripts are joined end to end and ligated
In contrast "normal" (cis-)splicing processes a single molecule. That is, trans-splicing results in an RNA transcript that came from multiple RNA polymerases on the genome. This phenomenon can be exploited for molecular therapy to address mutated gene products.
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- Coady TH, Shababi M, Tullis GE, Lorson CL (2007). "Restoration of SMN Function: Delivery of a Trans-splicing RNA Re-directs SMN2 Pre-mRNA Splicing". Molecular Therapy 15 (8): 1471-8.