Little is known of the personal circumstances of De la Cruz except that he was educated in Binalatongan and was orphaned in his teens. He then moved to Manila and worked as the coachman of the Spanish official Francisco Enriquez de Villacorta, a member of the Audiencia Real, which served as the privy council of the governor-general who governed the Philippines.
It was at this time that the principalia of Binalatongan protested the abuses committed by the provincial governor. The town leaders demanded that the governor be removed and that the colonial government stop collecting taxes since the islands were already under the British.
But the Spanish Governor General Simon de Anda dismissed the demands and the revolt broke out in November 1762. The name of De la Cruz, who began to be known as Palaris, emerged as one of the leaders of the revolt, along with his brother Colet, Andres Lopez and Juan de Vera Oncantin.
At the Battle of Agno River of 1763, he faced on March 1, 1763 the Spaniard Alfonso de Arayat, who led a composite troop of Spanish soldiers and Filipinos loyal to Spain. Arayat withdrew after losing much of his Filipino loyalists.
Filipinos took over all official functions and controlled the province up to the Agno River, the natural boundary between Pangasinan and neighboring Pampanga in the south. (The present-day province of Tarlac was still part of Pampanga.)
At the height of the uprising, Palaris commanded 10,000 men. He was also in communication with Silang, with whom he was coordinating a bigger offensive against the Spanish.
The Spanish friars, who were allowed to stay in the province, also started a campaign to persuade Pangasinan residents of the futility of the Palaris Revolt.
By September 1763, news of the peace treaty reached Pangasinan and amny of Palaris' men surrendered and returned to normal life amid the Spaish offensive.
Palaris tried to fend off the offensive at the village of Mabalitec near the Agno River between Binalatongan and Bayambang in December 1763. To prevent the Spanish from seeking lodging in his hometown, he ordered his men to raze Binalatongan.
But the Spanish won the Battle of Mabalitec, demoralizing Palaris' forces. The town of Binalatongan was rebuilt in another site between December 1763 to June 1764 and renamed San Carlos (now San Carlos City, Pangasinan), in honor of the reigning King Carlos III of Spain.
Palaris' forces made a last stand at the town of San Jacinto, Pangasinan, but they were defeated and Palaris' advisers, Andres Lopez and Juan de Vera Oncantin, were captured. They would later be hanged.
But his presence terrified his protectors and his own sister Simeona, who was apparently threatened by the Spanish clergy, betrayed him to Agustin Matias, the gobernadorcillo (mayor) of the razed Binalatongan.
Palaris was arrested on Jan. 16, 1765 and brought to the provincial capital of Lingayen for trial. While in detention, he confessed being the principal leader of the revol. He was convicted and hanged on Feb. 26, 1765. He was 32 years old.