By the end of the 1960s, most rural sections of I-40 were completed across the state with the largest exception being a 40-mile stretch east of Tucumcari to the Texas border at Glenrio, where traffic was diverted to the old U.S. 66. That section of highway by this time became locally and nationally known as "Slaughter Lane" due to tremendous amounts of traffic for a two-lane highway along with rough and narrow paving which led to numerous injury and fatal traffic accidents that reached epidemic numbers in 1968 and 1969. Construction on this section of I-40 was held up by a dispute at San Jon concerning a proposed routing of I-40 bypassing that city to the north by some five miles, which was resolved in November, 1969 when federal and state officials agreed to bring the bypass closer to the city along its northern limits. However, aside from a few small villages such as Montoya, Newkirk and Cuervo in the eastern portion of the state and Laguna, Budville and Cubero to the west, no major bypasses had been entirely completed in New Mexico so traffic was still diverted over the U.S. 66 routes through each of those cities.
In 1970, I-40 was entirely completed through the city of Albuquerque. Other bypasses were completed around various cities through the state including San Jon and Tucumcari (1981), Santa Rosa (1972), Moriarty (1973), Grants (1974) and Gallup (1980).
Eastbound
| County | Location | Mile | # | Destinations | Notes |
|---|---|---|---|---|---|
| McKinley | 8 | Defiance, Manuelito (NM 118/US 66) | |||
| Gallup | 16 | I-40 Bus. east; NM 118 - West Gallup (US 66) | |||
| 20 | US 491 north - Shiprock; NM 602 south - Munoz Boulevard, Zuni | ||||
| 22 | Miyamura Drive; Montoya Boulevard | ||||
| 26 | I-40 Bus. west - East Gallup (NM 118/US 66) | ||||
| 33 | NM 400 south - McGaffey (NM 118/US 66) | ||||
| 36 | Iyanbito (NM 118/US 66 west) | West end of US 66 overlap | |||
| 39 | Refinery | ||||
| 44 | Coolidge | ||||
| 47 | Continental Divide (NM 122/US 66 east) | East end of US 66 overlap | |||
| 53 | NM 371; NM 612 - Thoreau (NM 122/US 66) | ||||
| 63 | NM 412 - Prewitt (to NM 122/US 66) | ||||
| Cibola | 72 | Bluewater Village (NM 606 to NM 122/US 66) | |||
| Milan | 79 | I-40 Bus. east to NM 605; to NM 509 - Milan, San Mateo, Chaco Culture National Historical Park (NM 615 to NM 122/US 66) | |||
| Grants | 81 | NM 53 to I-40 Bus.; to NM 122 - San Rafael, Grants ( to US 66) | Signed as exits 81A (NM 53 south) and 81B (NM 53 north to I-40 Bus.) on I-40 east | ||
| 85 | I-40 Bus. west to NM 547 - Grants, Mt. Taylor (NM 122 west to US 66) | ||||
| 89 | Quemado (NM 117; NM 124 east; US 66) | ||||
| 96 | McCartys, Acoma, Sky City (NM 124/US 66) | ||||
| 100 | San Fidel | ||||
| 102 | Acomita, Acoma, Sky City | ||||
| 104 | Cubero, Budville (NM 124/US 66) | ||||
| 108 | Casa Blanca, Paraje (NM 23) | ||||
| 114 | NM 124 west - Laguna (US 66 west) | West end of US 66 overlap | |||
| 117 | Mesita | ||||
| 126 | NM 6 east - Los Lunas (pre-1937 US 66 east) | East end of pre-1937 US 66 overlap | |||
| 131 | To'hajiilee | ||||
| Bernalillo | 140 | Rio Puerco | |||
| 149 | Paseo del Volcan; Central Avenue (US 66 east) | East end of US 66 overlap | |||
| 153 | 98th Street | ||||
| Albuquerque | 154 | Unser Boulevard (NM 345) | |||
| 155 | Coors Boulevard | ||||
| 157A | Rio Grande Boulevard | ||||
| 157B | 12th Street | Westbound exit is via exit 158 | |||
| 158 | 8th Street; 6th Street | ||||
| 159A | 4th Street; 2nd Street; University Boulevard - Downtown (pre-1937 US 66; NM 47) | Signed as exit 159D westbound, since it is east of exit 159BC | |||
| 159BC | I-25 - Santa Fe, Las Cruces | ||||
| 160 | Carlisle Boulevard | ||||
| 161 | San Mateo Boulevard | Signed as exits 161A (south) and 161B (north) on I-40 east | |||
| 162 | Louisiana Boulevard | ||||
| 164 | Wyoming Boulevard - Kirtland AFB | ||||
| 165 | Eubank Boulevard | ||||
| 166 | Juan Tabo Boulevard | ||||
| 167 | Central Avenue (NM 333/US 66); Tramway Boulevard (NM 556) | ||||
| 170 | Carnuel (NM 333/US 66) | ||||
| 175 | NM 14; NM 337 - Tijeras, Cedar Crest (NM 333/US 66) | ||||
| 178 | Zuzax (NM 333/US 66) | ||||
| 181 | To NM 217 - Sedillo (NM 333/US 66) | ||||
| Santa Fe | Edgewood | 187 | NM 344 - Edgewood ( to NM 333/US 66) | ||
| Torrance | Moriarty | 194 | I-40 Bus. east to US 66 - Moriarty West (to NM 333 west) | ||
| 196 | NM 41 - Howard Cavasos Boulevard | ||||
| 197 | I-40 Bus. west; US 66 west - Moriarty East | West end of US 66 overlap; no westbound entrance | |||
| 203 | (no name) | ||||
| 208 | Wagon Wheel | ||||
| 218B | US 285 - Vaughn, Santa Fe | Signed as exit 218B on I-40 west, with exit 218A (Clines Corner) to the west | |||
| 226 | (no name) | ||||
| 230 | NM 3 - Encino, Villanueva | ||||
| 234 | Flying C | ||||
| 239 | (no name) | ||||
| Guadalupe | 243 | Milagro | Signed as exit 243B on I-40 west, with an unnamed exit 243A to the east | ||
| 252 | (no name) | ||||
| 256 | US 84 north - Las Vegas (pre-1937 US 66 west; NM 219 south) | West end of pre-1937 US 66/US 84 overlap | |||
| 263 | San Ignacio | ||||
| 267 | Colonias | ||||
| Santa Rosa | 273 | I-40 Bus. east - Santa Rosa (US 66 east; US 84 south) | East end of US 66/US 84 overlap | ||
| 275 | Santa Rosa (I-40 Bus.; US 54; US 66; US 84) | ||||
| 277 | I-40 Bus. west, US 54 west - Santa Rosa; US 84 - Fort Sumner (US 66 west; to NM 156 east) | West end of US 54/US 66 overlap | |||
| 284 | Frontage Road - Frontier Museum | ||||
| 291 | Cuervo (US 66 east) | East end of US 66 overlap | |||
| 300 | NM 129 - Newkirk ( to US 66) | ||||
| Quay | 311 | Montoya (US 66 west) | West end of US 66 overlap | ||
| 321 | Palomas | ||||
| Tucumcari | 329 | I-40 Bus. east; US 66 east - West Route 66 Boulevard | East end of US 66 overlap | ||
| 331 | Camino del Coronado | ||||
| 332 | NM 209 to NM 104 west - 1st Street | ||||
| 333 | US 54 east - Mountain Road | East end of US 54 overlap | |||
| 335 | I-40 Bus. west; US 66 | ||||
| 339 | NM 278 south (US 66; NM 286 north) | ||||
| 343 | (no name; US 66) | ||||
| San Jon | 356 | NM 469 to US 66 - San Jon | |||
| 361 | Bard (to US 66) | ||||
| 369 | NM 93 south - Endee; NM 392 north |