Born George Vincent Homeier, he began acting as Skippy Homeier at the age of six, on the radio show Portia Faces Life. From 1943 until 1944 he played the role of Emil in the Broadway play, Tomorrow the World. Cast as a child indoctrinated into Nazism, who is brought to the United States from Germany following the death of his parents, Homeier was praised for his performance. He played the troubled youngster in the 1944 film adaptation and received good reviews playing opposite Fredric March and Betty Field as his American uncle and aunt.
Although he worked frequently throughout his childhood and adolescence, he did not become a major star, but was able to make a transition from child actor to adult, especially in a range of roles as delinquent youths, common in Hollywood films of the 1950s. He played a killer opposite Gregory Peck in The Gunfighter (1950) and also played strong character roles in two of Sam Fuller's war films, Halls of Montezuma (1950) and Fixed Bayonets (1951). He also appeared with Randolph Scott in the Budd Boetticher western films, The Tall T (1957) and Comanche Station (1960), as wayward youths with no chance of redemption. He appeared in The Ghost and Mr. Chicken (1966) with Don Knotts. Homeier frequently appeared as a guest star, usually a villain, in all four of Irwin Allen's sci-fi series in the mid to late 1960s. He guest-starred in two episodes of the original Star Trek television series, Patterns of Force, and The Way to Eden. He has been retired since the mid-1980s.