Sistine Chapel [for Sixtus IV], private chapel of the popes in Rome, one of the principal glories of the Vatican. Built (1473) under Pope Sixtus IV, it is famous for its decorations. By far the best-known achievements in the chapel are the work of Michelangelo. Across the ceiling he painted nine episodes from Genesis. There are representations of the stages of creation, Adam and Eve's temptation and fall, and Noah and the Deluge. Below these scenes are the statuesque figures of prophets and sibyls, with episodes from the Old Testament in the spandrels, all designed to prefigure the salvation of Christianity. The last great work Michelangelo executed in the chapel is The Last Judgment, on the altar wall.

Frescoes by Perugino, Pinturicchio, Botticelli, Ghirlandaio, Rosselli, and Signorelli cover the side walls of the chapel. They depict scenes from the lives of Moses and Jesus, symbolizing the reign of law and of grace, respectively. There are also varicolored marble mosaics on the chapel's floor. Another treasure of the chapel is its collection of illuminated music manuscripts in the archives of the choir.

In 1980 cleaning and restoration of Michelangelo's frescoes began with the test cleaning of small areas; full-scale work started the following year and was completed in 1994. The cleaning became controversial as it proceeded, as many experts accused the restorers of distorting or destroying the frescoes, but others defended the work, astonished at the colorist that the restoration revealed the artist to be. The cleaning of chapel frescoes by Botticelli, Perugino, and other painters was completed in 1999.

Papal chapel in the Vatican Palace, Rome, constructed 1473–81 by Giovanni dei Dolci for Pope Sixtus IV (for whom it is named). It is the site of the principal papal ceremonies. Its exterior is drab and unadorned, but its interior walls and ceiling are decorated with frescoes by Florentine Renaissance masters, including Perugino, Pinturicchio, Sandro Botticelli, Domenico Ghirlandaio, and Luca Signorelli. Portions of the walls were once covered with tapestries designed by Raphael (1515–19). The most important works are the frescoes by Michelangelo on the ceiling and the western wall behind the altar, considered among the greatest achievements of Western painting. The ceiling frescoes, depicting Old Testament scenes, were commissioned by Pope Julius II and painted 1508–12; the Last Judgment fresco on the western wall was painted 1536–41 for Pope Paul III. A controversial 10-year cleaning and restoration of the ceiling was completed in 1989, and of the western wall in 1994.

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