Film

• Signs of Life (1968 film), by Werner Herzog
• Signs of Life (1989 film), a U.S. film

Literature

• Signs of Life (novel) by M. John Harrison
• Signs of Life, a book of poetry by John Gierach

Music

• Signs of Life (Billy Squier album)
• Signs of Life (EP), by Every Move a Picture
• Signs of Life (Pink Floyd song)
• Signs of Life (Poets of the Fall album)
• Signs of Life (Steven Curtis Chapman album)
• Signs of Life, a 1987 album by the Penguin Cafe Orchestra
• Signs of Life, a 1998 album by Martin Carthy
• Signs of Life, a 2004 album by Nemo