Khorsandi performs stand-up comedy, having been a noted performer at Joe Wilson's Comedy Madhouse in 1997. She has appeared on many BBC Radio 4 programmes, including Quote... Unquote, Loose Ends, You and Yours, Midweek, Just A Minute, The Now Show and The News Quiz. She also writes an occasional column for online magazine Iranian.com.
In 2007, she made her first trip to Australia and the Melbourne Comedy Festival with her show "Asylum Speaker". She also appeared live on the Australia comedy talk show Rove in 2007. She is married to fellow comedian Christian Reilly.