Cruzeiro do Sul was one of the oldest airlines of Brazil, it could trace its origins to 1926. In 1993 it was merged into Varig
The Junkers Ju 52 were replaced with Douglas DC-3 and by 1953 Cruzeiro had a fleet of 38 Dakotas flying. The next aircraft to be used was the Convair CV-240 and the Conviar CV-440 with services throughout Brazil and international services to extended to Montevideo, Uruguay, La Paz, Bolivia and Caracas, Venezuela.
The first jet aircraft was the SE.210 Caravelle followed by the Boeing 727-100 and Boeing 737-200. By 1975 Varig had acquired a majority in Cruzeiro do Sul and the route networks were rationalized. The last aircraft type to join the fleet before the integration into Varig was the Airbus A300B4. In January 1993 Cruzeiro do Sul ceased to exist when it was fully absorbed into Varig.