The process involves infecting a series of host organisms with a virus. Each time the virus is given some time to incubate, and then the next host is infected with the incubated virus. The virus may mutate repeatedly into a form that is resistant to a wide variety of host immune system defenses, or a weaker strain may result.
Pasteur produced an early rabies vaccine by using serial passage to transmit the virus until an attenuated developed which could be used to stimulate an immune response without causing a pathological infection.
Serial passage is also used in antimicrobial testing to determine how quickly an organism can acquire resistance to an antibiotic.
Effects of Serial Passage on the Characteristics and Chondrogenic Differentiation of Canine Umbilical Cord Matrix Derived Mesenchymal Stem Cells
Apr 01, 2013; INTRODUCTION A significant number of mesenchymal stem cells (MSCs) are needed for clinical applications which require extensive...
HUMAN EMBRYONIC STEM CELL (hES) COLONIES DISPLAY A HIGHER DEGREE OF SPONTANEOUS DIFFERENTIATION WHEN PASSAGED AT LOWER DENSITIES
Mar 01, 2006; SUMMARY Human embryonic stem (hES) cells require cooperative interactions with each other for their survival. Previously, the...