Semien Gondar is bordered on the south by Lake Tana, Mirab (West) Gojjam and the Benishangul-Gumuz Region, on the west by Sudan, on the north by the Tigray Region, on the east by Wag Hemra and on the southeast by Debub Gondar. Towns and cities in Semien Gondar include Debarq, Emfranz, Gondar, Gorgora and Metemma.
According to a May 24, 2004 World Bank memorandum, 7% of the inhabitants of Semien Gondar have access to electricity, this zone has a road density of 21.2 kilometers per 1000 square kilometers (compared to the national average of 30 kilometers), the average rural household has 1.2 hectare of land (compared to the national average of 1.01 hectare of land and an average of 0.75 for the Ahmara Region) and the equivalent of 0.8 heads of livestock. 24.6% of the population is in non-farm related jobs, compared to the national average of 25% and a Regional average of 21%. 50% of all eligible children are enrolled in primary school, and 13% in secondary schools. 62% of the zone is exposed to malaria, and none to Tsetse fly. The memorandum gave this zone a drought risk rating of 506.