Njimoluh was the son of Ibrahim Njoya, and he was educated in French, English, and the shu mom script developed by his father. In 1931, in order to break the power of the Bamun, French administrators exiled Ibrahim Njoya to Yaoundé. The Bamun nobles had been scattered by the French occupation, but they eventually chose Njimoluh from among Ibrahim Njoya's 177 children and reached an agreement with the French authorities. Seidou Njimoluh Njoya became the Bamun ruler in June 1933 after the death of his father.
Njoya later served on the legislative and national assemblies of Cameroon during both colonial and post-colonial periods. Njimoluh was a patron of the arts and worked to preserve Bamun culture. After the French left in 1960, he restored the sacred Bamun idols to the Royal Palace, establishing a museum. He was a devout Muslim and was married to Noh Lantana. Njimoluh was succeeded by his son Ibrahim Mbombo Njoya.