On June 11, 2008, Powell fought Deandre Latimore at the Hard Rock Cafe in New York City. Powell entered the fight ranked #1 by the IBF in the junior middleweight division. Both men hurt each other repeatedly throughout the fight, but it was Latimore who came up big in the seventh round when he hurt Powell with a right hook. An uppercut rocked Powell along the ropes and his head was repeatedly snapped back as he absorbed punch after punch. With less than a minute left in the round, the referee stepped in and called it off, much to the dismay of Powell. At the time of the stoppage, all three judges had the fight even, 57-57. Powell tested positive for marijuana in his post-fight drug test and was suspended for 60 days by the New York State Athletic Commission.