The Santa Fe Swamp
is 95-percent floodplain 7,046-acre (28.5 km²) swamp. Along with Lake Santa Fe
and Little Lake Santa Fe, it serves as headwaters
of the Santa Fe River
, which drains into the Suwannee River
and then finally the Gulf of Mexico
. It is located to the north of those lakes in Alachua County
The 5,356-acre (21.7 km²) Santa Fe Swamp Wildlife and Environmental Area (WEA) was donated to the Suwannee River Water Management District in 1984 by Georgia-Pacific Corporation. At that time, it was the largest and most environmentally significant donation in the state of Florida's history.