Born in Salem, Massachusetts to two unwed first cousins, Jones Very became associated with Harvard University, first as an undergraduate, then as a student in the Harvard Divinity School and as a tutor of Greek. He began studying epic poetry and was invited to lecture on the topic in his home town, which drew the attention of Ralph Waldo Emerson. Soon, Very began asserting that he was the Second Coming of Christ, resulting in his dismissal from Harvard and his eventual institutionalization in an insane asylum. When he was released, Emerson helped him issue a collection called Essays and Poems in 1839. Very lived the majority of his life as a recluse from then on, issuing poetry only sparingly. He died in 1880.
Becoming known for his ability to draw people into literature, Very was asked to speak at a lyceum in his hometown of Salem in 1837. There, he was befriended by Elizabeth Peabody, who wrote to Emerson suggesting Very lecture in Concord as well. In 1838, Ralph Waldo Emerson was convinced to arrange a talk by Very at the Concord Lyceum. Very lectured on epic poetry on April 4 of that year after having walked twenty miles from Salem to Concord to deliver it. and Emerson made up for the meager $10 payment by inviting Very to his home for dinner. Emerson signed Very's personal copy of Nature with the words: "Har[mony] of Man with Nature Must Be Reconciled With God".
For a time, Very tried to recruit Nathaniel Hawthorne as a brother figure in his life. Though Hawthorne treated him kindly, he was not impressed by Very. Unlike Hawthorne, however, Emerson found him "remarkable" and, when Very showed up at his home unannounced along with Cornelius Conway Felton in 1838, Emerson invited several other friends including Henry David Thoreau to meet him. Emerson, however, was surprised at Very's behavior in larger groups. "When he is in the room with other persons, speech stops, as if there were a corpse in the apartment", he wrote. Even so, in May 1838, the same month Very published his "Epic Poetry" lecture in the Christian Examiner, Emerson brought Very to a meeting of the Transcendental Club, where the topic of discussion was "the question of mysticism". At the meeting, held at the home of Caleb Stetson in Medford, Massachusetts, Very was actively engaged in the discussion, building his reputation as a mystic within that circle.
One of Very's students, a fellow native of Salem named Samuel Johnson, Jr., said that people were ridiculing Very behind his back since he had "gained the fame of being cracked (or crazy, if you are not acquainted with Harvard technicalities)". During one of his tutoring sessions, Very declared that he was "infallible: that he was a man of heaven, and superior to all the world around him". He then cried out to his students, "Flee to the mountains, for the end of all things is at hand". Harvard president Josiah Quincy III relieved Very of his duties, referring to a "nervous collapse" that required him to be left in the care of his younger brother Washington Very, himself a freshman at Harvard. After returning to Salem, he visited Elizabeth Peabody on September 16, 1838. As she recalled,
After this, Very told her she would soon feel different, explaining, "I am the Second Coming". He performed similar "baptisms" to other people throughout Salem, including ministers. It was finally Reverend Charles Wentworth Upham who had had committed.
Very was institutionalized for a month at a hospital near Boston, the McLean Asylum, as he wrote, "contrary to my will". While there, he finished an essay on Hamlet, arguing that the play is about "the great reality of a soul unsatisfied in its longings after immortality" and that "Hamlet has been called mad, but as we think, Shakespeare thought more of his madness than he did of the wisdom of the rest of the play". He was released on October 17, 1838, though he refused to renounce his beliefs. As he left, other patients reportedly thanked him as he left. That same month, Very stayed with Emerson at his home in Concord for a week. While he was visiting, Emerson wrote in his journal on October 29, "J. Very charmed us all by telling us he hated us all."
Amos Bronson Alcott wrote of Very in December 1838:
Very continued writing throughout his life, though sparingly. Many of his later poems were never collected but only distributed in manuscript form among the Transcendentalists. In January 1843, his work was included in the first issue of The Pioneer, a journal edited by James Russell Lowell which also included the first publication of Edgar Allan Poe's "The Tell-Tale Heart".
Jones Very believed his role as a prophet would last only twelve months. By September 1839, his role was complete. The last years of Very's life were spent in Salem as a recluse under the care of his sister. It was during these years that he held roles as a minister in Eastport, Maine and North Beverly, Massachusetts, though these roles were temporary because he was too shy. By age 45, he had retired. He died in 1880 and, upon hearing of Very's death, Alcott wrote a brief remembrance on May 16, 1880: