Homobonus was able to pursue this calling in life easily as a result of the inheritance he received from his father, a prosperous tailor and merchant. He practiced his business at Cremona with scrupulous honesty. He also donated a large proportion of his profits to the relief of the poor.
Homobonus was a frequent church attendee that would partake in the Eucharist everyday. While attending mass, prostrated in the form of a cross, on November 13, 1197, Homobonus died. Two years later Homobonus was canonized by Pope Innocent III. During Homobonus's canonization Pope Innocent III said that Homobonus was a "father of the poor", "consoler of the afflicted", "assiduous in constant prayer", "man of peace and peacemaker", "a man good in name and deed", "this saint, is still like a tree planted by streams of water that yields its fruit in our time."
He is the patron saint of business people, tailors, shoemakers, and clothworkers, as well as of Cremona itself. He was canonized in 1199 at the urgent request of the citizens of Cremona. His feast day is celebrated on November 13.