A sacrifice is the practice of offering food, or the lives of animals or people to the gods, as an act of propitiation or worship.

Sacrifice may also refer to:

In games:

• Sacrifice (bridge), a strategy in bridge
• Sacrifice (chess), a move in chess
• Sacrifice bunt or Sacrifice fly, plays in baseball
• Sacrifice (computer game), a 3D real-time strategy game

In music:

• "Sacrifice", a song by t.A.T.u. from the album Dangerous and Moving
• "Sacrifice", a song by the Jedi Mind Tricks from their album Violent By Design
• Sacrifice (Gary Numan album), an album by Gary Numan
• Sacrifice (Motörhead album), an album by Motörhead
• Sacrifice (Black Widow album), an album by "Black Widow" (band)
• "Sacrifice" (song), an Elton John song
• Sacrifice (Anouk song), an Anouk song
• "Sacrifice", a song by Screaming Jets from their 1994 album The Screaming Jets
• "Sweet Sacrifice", a recent single by Evanescence

In television and film:

• TNA Sacrifice, a Total Nonstop Action Wrestling pay-per-view event
• "Sacrifice" (Angel), an episode of Angel
• "Sacrifice" (Battlestar Galactica), an episode of Battlestar Galactica
• The Sacrifice (1986 film), a film by Andrei Tarkovsky
• The Sacrifice (2005), an independent film
• "Sacrifice" (Blade: the Series), an episode of Blade: The Series
• "Sacrifices" (Stargate SG-1), an episode of Stargate SG-1

In books:

• Sacrifice, a 1991 novel by Andrew Vachss
• Sacrifice (novel), the fifth novel in the Legacy of the Force series