SOB may refer to: Music and media
- S.O.B. (1981 film)
- S.O.B. (band), a Japanese punk band
- "S.O.B.s", an episode of the TV series Arrested Development
- Scars on Broadway, a side project of two members of the band System of a Down
- Sons of Batman, a group of characters in a Batman comics miniseries
- Sons of Butcher (band), a Canadian rock band
- Styles of Beyond, an underground rap group
- Super Optimal Broth, a bacterial growth media
- Switched-On Bach, an album by Walter CarlosTransport
- Seaford-Oyster Bay Expressway
- Balaton Airport, SOB in IATA code
- Southbourne railway station, SOB in Network Rail codeOther meanings
- Seventeen or Bust, a distributed computing project
- Shortness of breath, a perceived difficulty of breathing
- Sobralia, a genus of orchids
- Son of a bitch, an insult
- Sons of Ben (MLS supporters association)
- Suggested Opening Bid, a term in auctioneering
- Super Oralloy Bomb, a nuclear bomb
- Special Operations Battalion (SOB), an elite unit of the Croatian army