This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Report Summarizes Neuroscience Study Findings from University of Cambridge, Center for Stem Cell Biology and Regenerative Medicine.
Jan 26, 2011; Investigators publish new data in the report 'Retinoid X receptor gamma signaling accelerates CNS remyelination.' "The molecular...