In 1934 Rena Galibova married to a known Bukharian writer, Gavriel Samandarov, and in 1938 they moved to Stalinabad (now Dushanbe), Tajikistan. There Rena Galibova continued her theatrical career in the Theater of Opera and Ballet where she took on many leading roles. In 1939, Rena Galibova was awarded the title of Merited Artist of Tajikistan and in 1941 she was given the title of People’s Artist of Tajikistan.
During the WWII Rena Galibova was one of many Bukharian Jewish artists who performed throughout the USSR in the war effort. After the war Rena Galibova continued to perform in many cities and towns of the USSR. In 1957 she was welcomed on the scene of Bolshoi Theater in Moscow. Later in her life Rena Galibova moved to the United States and lived in Boston, where she died at the age of 80 in 1995. Her gravestone, in Mount Carmel Cemetery, Brooklyn, reads "Honored Artist of Tajikistan".