• Hendrik Brugmans (1950-1972)
• Jerzy Lukaszewski (1972-1990)
• Werner Ungerer (1990-1993)
• Gabriel Fragnière (1993-1995)
• Otto von der Gablentz (1996-2001)
• Piet Akkermans (2001-2002)
• Robert Picht (Rector ad interim) (2002-January 31 2003)
• Paul Demaret (2003-)

A second campus was opened at the invitation of the Polish government in Natolin (Warsaw) in 1992. Vice-rectors of the College of Europe's Natolin (Warsaw) campus:

• Ettore Deodato (1993)
• D. Lewis (1994-1996)
• Jacek Saryusz-Wolski (1996-1999)
• Piotr Nowina-Konopka (1999-2004)
• Robert Picht (Vice-Rector ad interim) (2004-2005)
• Robert Picht (2005-2007)
• Ewa Ośniecka-Tamecka (2007-)