In 1469 Richard Neville, 16th Earl of Warwick rebelled against Edward along with Edward's younger brother, George, Duke of Clarence, and after a failed rebellion in 1470 they both fled to France, where they encountered Margaret of Anjou, the wife of Henry VI. This was a difficult situation as Warwick had played a huge role in helping Edward win the throne in 1461. However, after tense negotiations Warwick, Clarence and Margaret came to a deal whereby in return for French aid with an invasion, Warwick and Clarence would help restore Henry VI to the throne. Henry VI's son, Edward of Westminster, Prince of Wales, would be his heir, but if Westminster died then Clarence would become heir to the throne. This alliance was sealed by the marriage of Warwick's youngest daughter Anne Neville to Westminster.
Warwick's brother, John Neville, 1st Marquess of Montagu deserted Edward IV when Warwick invaded in 1470, and when Edward realised he could not stand against Warwick's army, he fled to Burgundy, to his brother-in-law Charles, Duke of Burgundy. Warwick entered London in triumph, and freed Henry VI from the Tower.
The Readeption of Henry VI took place on 3 October 1470. However, by this point Henry was too mentally feeble to rule unaided; for example, he had to be led by the hand when he paraded through London.
Henry's return to the throne did not last long. Edward, after gaining Burgundian support, landed in Holderness in March 1471, and after a success at the Battle of Barnet on 14 April where Warwick was killed, Edward was victorious at the Battle of Tewkesbury where the Lancastrian male line was virtually destroyed; Westminster was killed, and the Beaufort family was extinguished in the male line. Edward IV entered London on 21 May, and it appears (although it is not certain) that Henry VI was killed that night, thus ending his brief second reign.