Up to three simultaneous players control the monsters George (a King Kong-like gorilla), Lizzie (a Godzilla-like dinosaur/lizard), or Ralph (a giant werewolf), created from humans who were mutated by experiments conducted at Scumlabs. They need to destroy all buildings in a high-rise city to advance to the next city. On their way they can destroy helicopters, tanks, taxis, police cars, boats, and trolleys, as well as eat people.
The monsters can jump and climb buildings, and attack enemies and buildings with punches. Some buildings also take damage when jumped on.
The player receives damage from enemy bullets, grenades, shells, etc., or from falls. Damage can be recovered by eating the right food, such as fruit, roast chicken, or soldiers. If a monster takes too much damage, it reverts back into a naked human and starts walking off the screen sideways covering themselves with their hands. If the player continues, the human will mutate back into the monster with a full life bar.
The game was developed as an arcade game for Midway by Game Refuge Inc. designers Brian Colin and Jeff Nauman, who conceived and designed the original back in 1986. It was then ported to the Sega Saturn, Nintendo 64, Game Boy Color, PlayStation, Microsoft Windows and as a download on the Playstation 3's Playstation Network. It has also been re-released on Midway Arcade Treasures 2 as well as being an unlockable in Rampage: Total Destruction.
In this game, the player has some control over the course of the game. In the first level, Peoria, a tourism billboard cycles through different regions in the country (Northeast, Southwest, etc). Destroying the billboard when it is showing one of these regions will send the player in that direction. Players may also choose to eat or ignore the "World Tour" powerups and control whether they leave the country. The game will not end until every Scum Labs city has been destroyed, which may cause some erratic traveling around towards the end of the game (including multiple world tour trips if the players have missed or purposely kept from getting world tour flags).
A Humorous effect is taken if your monster eats some specific civilians, such as eating people garbed in church clothes will cause lightning to strike your monster. If your monster eats a toxic waste canister at a Scumlabs facility, the monster will turn into a flying monster named V.E.R.N. until the level ends. He also appears in the Wii version of Rampage: Total Destruction.