Pyrogallol hydroxytransferase

Pyrogallol hydroxytransferase

In enzymology, a pyrogallol hydroxytransferase is an enzyme that catalyzes the chemical reaction

1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene rightleftharpoons 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene

Thus, the two substrates of this enzyme are 1,2,3,5-tetrahydroxybenzene and 1,2,3-trihydroxybenzene, whereas its two products are 1,3,5-trihydroxybenzene and 1,2,3,5-tetrahydroxybenzene.

This enzyme belongs to the family of oxidoreductases. The systematic name of this enzyme class is 1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase. Other names in common use include 1,2,3,5-tetrahydroxybenzene hydroxyltransferase, 1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase, 1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase), pyrogallol hydroxyltransferase, 1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase. This enzyme participates in benzoic acid degradation via CoA ligation.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .

References

  • Brune A, Schink B "Pyrogallol-to-phloroglucinol conversion and other hydroxyl-transfer reactions catalyzed by cell extracts of Pelobacter acidigallici". J. Bacteriol. 172 1070–6.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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