a pyrimidodiazepine + glutathione disulfide + H₂O $rightleftharpoons$ 6-pyruvoyltetrahydropterin + 2 glutathione

The 3 substrates of this enzyme are pyrimidodiazepine, glutathione disulfide, and H₂O, whereas its two products are 6-pyruvoyltetrahydropterin and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a disulfide as acceptor. The systematic name of this enzyme class is pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Other names in common use include PDA synthase, pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening,, and cyclizing). This enzyme participates in glutathione metabolism.

References

• Wiederrecht GJ, Brown GM "Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins". J. Biol. Chem. 259 14121–7.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes