Pygopristis denticulata is a species of piranha and is the only species of the genus Pygopristis. It is a rare South American fish found in the Orinoco River basin, north and eastern Guiana Shield rivers, and tributaries of the lower Amazon River.

Pygopristis has pentacuspid teeth and a middle cusp that is usually only slightly larger than the other cusps. This is unlike other piranha, which have tricuspid teeth with a larger middle cusp making the teeth appear triangular.

P. denticulata grows to about 20.0 centimetres (7.9 in) TL. P. denticulata has 62 chromosomes.

This fish possesses powerful dentition that can cause serious bites.

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