, a pteridine reductase
is an enzyme
the chemical reaction
- 5,6,7,8-tetrahydrobiopterin + 2 NADP+ biopterin + 2 NADPH + 2 H+
Thus, the two substrates of this enzyme are 5,6,7,8-tetrahydrobiopterin and NADP+, whereas its 3 products are biopterin, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase. Other names in common use include PTR1, and pteridine reductase 1.
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and .
- Nare B, Hardy LW, Beverley SM "The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major". J. Biol. Chem. 272 13883–91.
- SM, Hunter WN "Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites". Nat. Struct. Biol. 8 521–5.
- Fitzpatrick PF "The aromatic amino acid hydroxylases". Adv. Enzymol. Relat. Areas. Mol. Biol. 74 235–94.
- The CAS registry number for this enzyme class is .