Definitions

Protein kinase domain

Protein kinase domain

Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. The enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine specific and tyrosine specific.

Protein kinase function has been evolutionarily conserved from Escherichia coli to Homo sapiens. Protein kinases play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins.

The catalytic subunits of protein kinases are highly conserved, and several structures have been solved, leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases. Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme.

Human proteins containing this domain

AAK1; ACVR1; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; ADRBK1; ADRBK2; AKT1; AKT2; AKT3; ALS2CR2; ALS2CR7; AMHR2; ANKK1; ARAF; AURKA; AURKB; AURKC; BMP2K; BMPR1A; BMPR1B; BMPR2; BRAF; BRSK1; BRSK2; BUB1; C14orf20; CAMK1; CAMK1D; CAMK1G; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; CAMKK2; CAMKV; CASK; CCRK; CDC2; CDC2L1; CDC2L2; CDC2L5; CDC2L6; CDC42BPA; CDC42BPB; CDC42BPG; CDC7; CDK10; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK8; CDK9; CDKL1; CDKL2; CDKL3; CDKL4; CDKL5; CHEK1; CHEK2; CHUK; CIT; CLK1; CLK2; CLK3; CLK4; CRKRS; CSNK1A1; CSNK1A1L; CSNK1D; CSNK1E; CSNK1G1; CSNK1G2; CSNK1G3; CSNK2A1; CSNK2A2; DAPK1; DAPK2; DAPK3; DCAMKL1; DCLK1; DCLK2; DCLK3; DMPK; DYRK1A; DYRK1B; DYRK2; DYRK3; DYRK4; EIF2AK1; EIF2AK3; EIF2AK4; ERN1; ERN2; GAK; GRK1; GRK4; GRK5; GRK6; GRK7; GSK3A; GSK3B; GUCY2C; GUCY2D; GUCY2F; HIPK1; HIPK2; HIPK3; HIPK4; HUNK; ICK; IKBKB; IKBKE; IRAK1; IRAK2; IRAK3; IRAK4; KALRN; KIAA0999; KSR2; LATS1; LATS2; LIMK1; LIMK2; LOC402468; LOC407835; LRRK1; LRRK2; MAK; MAP2K1; MAP2K2; MAP2K3; MAP2K4; MAP2K5; MAP2K6; MAP2K7; MAP3K1; MAP3K10; MAP3K11; MAP3K12; MAP3K13; MAP3K14; MAP3K15; MAP3K2; MAP3K3; MAP3K4; MAP3K5; MAP3K6; MAP3K7; MAP3K8; MAP3K9; MAP4K1; MAP4K2; MAP4K3; MAP4K4; MAP4K5; MAPK1; MAPK10; MAPK12; MAPK13; MAPK14; MAPK15; MAPK3; MAPK4; MAPK6; MAPK7; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MAPKAPK5; MARK1; MARK2; MARK3; MARK4; MAST1; MAST2; MAST3; MAST4; MASTL; MELK; MELKv2; MELKv3; MINK; MINK1; MKNK1; MKNK2; MLK4; MLKL; MOS; MST094; MST4; MYLK; MYLK2; MYLK3; MYO3A; MYO3B; NEK1; NEK10; NEK11; NEK2; NEK3; NEK4; NEK5; NEK6; NEK7; NEK8; NEK9; NIM1; NLK; NPR2; NRBP1; NRK; NUAK1; NUAK2; OBSCN; OXSR1; PAK1; PAK2; PAK3; PAK4; PAK6; PAK7; PASK; PBK; PCTK1; PCTK2; PCTK3; PDIK1L; PDPK1; PDPK2; PFTK1; PHKG1; PHKG2; PIK3R4; PIM1; PIM2; PIM3; PINK1; PKMYT1; PKN1; PKN2; PKN3; PLK1; PLK2; PLK3; PLK5; PNCK; PRKAA1; PRKAA2; PRKACA; PRKACB; PRKACG; PRKCA; PRKCB1; PRKCD; PRKCE; PRKCG; PRKCH; PRKCI; PRKCN; PRKCQ; PRKCZ; PRKD1; PRKD2; PRKD3; PRKG1; PRKG2; PRKX; PRKY; PRPF4B; PSKH1; PSKH2; QSK; RAF1; RAGE; RIP3; RIPK1; RIPK2; RIPK3; RIPK4; RIPK5; RK; RNASEL; ROCK1; ROCK2; RPS6KA1; RPS6KA2; RPS6KA3; RPS6KA4; RPS6KA5; RPS6KA6; RPS6KB1; RPS6KB2; RPS6KC1; RPS6KL1; SBK1; SCYL2; SCYL3; SGK; SGK069; SGK071; SGK085; SGK110; SGK196; SGK2; SGK269; SGK3; SGK494; SGKL; SLK; SNF1LK; SNF1LK2; SNRK; SPEG; SRPK1; SRPK2; SRPK3; STK10; STK11; STK16; STK17A; STK17B; STK24; STK25; STK3; STK31; STK32A; STK32B; STK32C; STK33; STK35; STK36; STK38; STK38L; STK39; STK4; STK40; STRAD; TAK1; TAOK1; TAOK2; TAOK3; TBCK; TBK1; TESK1; TESK2; TGFBR1; TGFBR2; TLK1; TLK2; TNIK; TRIB1; TRIB2; TRIB3; TRIO; TSSK1; TSSK1B; TSSK2; TSSK3; TSSK4; TSSK6; TTBK1; TTBK2; TTK; TTN; UHMK1; ULK1; ULK2; ULK3; ULK4; VRK1; VRK2; WEE1; WEE1B; WNK1; WNK2; WNK3; WNK4; YSK4; dik;

References

Search another word or see Protein kinase domainon Dictionary | Thesaurus |Spanish
Copyright © 2014 Dictionary.com, LLC. All rights reserved.
  • Please Login or Sign Up to use the Recent Searches feature