UDP-N-acetylglucosamine + [Skp₁-protein]-hydroxyproline $rightleftharpoons$ UDP + [Skp₁-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline

Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and [Skp1-protein-hydroxyproline]], whereas its two products are UDP and [Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline]].

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl-transferase. Other names in common use include Skp1-HyPro GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide, GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, and UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase.

References

• CM "Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of dictyostelium". J. Biol. Chem. 277 46328–37.
• Teng-Umnuay P, van der Wel H, West CM "Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium". J. Biol. Chem. 274 36392–402.
• West CM, van der Wel H, Gaucher EA "Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins". Glycobiology. 12 17R–27R.

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