In urologic pathology, high-grade prostatic intraepithelial neoplasia, abbreviated HGPIN, is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). It is considered to be a pre-malignancy, or carcinoma in situ, of the prostatic glands.

On a subsequent biopsy, given a history of a HGPIN diagnosis, the chance of finding prostatic adenocarcinoma is approximately 30%.

Histology

HGPIN typically has one of four different histologic patterns:

• tufted,
• micropapillary,
• cribriform and,
• flat.

Its cytologic features are that of prostatic adenocarcinoma:

• presence of nucleoli,
• increased nuclear-to-cytoplasmic ratio and,
• increased nuclear size.

See also

• Atypical small acinar proliferation

References

External links

• Prostatic intraepithelial neoplasia - prostate-cancer.org.