Propantheline bromide (INN) is an antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions.
By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm
of the muscle in the gut. Relaxing the smooth muscle in the bladder
prevents the involuntary spasms that can allow leakage of urine
from the bladder in the condition known as enuresis
(involuntary urination in adults). Propantheline can also be used to treat excessive sweating
because acetylcholine block also reduces secretions such as sweat and tears
, hypersensitivity to light
, dry mouth, and urinary retention
Mechanism of action
Propantheline is one of a group of antispasmodic
medications which work by blocking the action of the chemical messenger acetylcholine
, which is produced by nerve cells, to muscarinic receptors
present in various smooth muscular
tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.