Prokuplje (Serbian Прокупље) is a town and municipality located in Serbia at 43.24° North, 21.59° East. In 2002 the town had a total population of 27,673, while population of municipality was 48,501. It is the administrative center of the Toplica District of Serbia.
Municipality of Prokuplje is located between municipalities of Blace, Kuršumlija, Bojnik, Žitorađa, Merošina, Aleksinac, and Kruševac.