Years later, Ivo discovered an immortality potion and drank it, but found that the immortality brought with it horrible disfigurement that made his skin scaly. He blamed this on the JLA and drifted further into insanity as he attacked the League on numerous occasions. Ivo built duplicates of himself to keep him company. These duplicates were repulsed by the insanity of their creator and locked him away, then carried out his dreams of revenge by attacking the new Justice Leaguers (Vibe, Gypsy, Steel and Vixen) and killing Vibe.
A year later, Ivo built a private island populated by robots. There, Ivo created "Men In Black" nicknamed Amazoids who had similar powers to Amazo. The Amazoids could steal one superpower each; they succeeded in robbing the powers of Red Star, Rebis, Valor, Power Girl, Starman and Geo-Force. However, this time Ivo's goal was not revenge, but suicide. Ivo realized that the disfigurement was not the side effect; it was the immortality. His body was becoming more and more infected, more and more immobile, until he would be nothing but a pain-filled living statue. Fearing this even more than death, he ordered the Amazoids to turn their full power on him. It didn't work. The JLA'er Ice, sympathizing with him, unknowingly invoked the power of Guy Gardner's Green Lantern ring to cure him.
Professor Ivo's disfiguring experience was not enough to keep him from the temptation of the immortality serum and he once again brought about his own deformity by drinking it. As both Ice and the Green Lantern rings were gone, Ivo apparently consigned himself to his own horrible fate and was later imprisoned.
Most recently, Professor Ivo has returned in Brad Meltzer's Justice League of America sans disfigurement. However, in a fight with Black Canary, Arsenal and Green Lantern, he claims to still retain his immortality. In Infinite Crisis, he was seen a member of the Secret Society of Super Villains. In Justice League of America #4, it is revealed that he is not the mastermind of the events, but rather working for an intelligent Solomon Grundy. It appears Grundy is using Ivo to build him an Amazo body to live forever.
He also took part in the Salvation Run storyline.
The Secret Society of Super Villains also assigned him to collect soil samples in Auschwitz, Poland which will be used to create the Wonder Woman villain Genocide. Ivo brings along his newest android Red Volcano as an aid. During this mission it is revealed that Ivo isn't in agreement to create the new villain but follows through with orders at the prospect of having other Secret Society members create an antidote for his physical disfigurement.
Professor Ivo created a serum which provides him with an extremely long life span. The serum has however left his body twisted and malformed. As a result of his "immortality" serum, Ivo has developed a thick, resilient second skin. The skin appears to be bullet proof, and impenetrable to most forms of energy.
Professor Ivo (listed on the computer screen at one point as Arthur Ivo) appeared in the Justice League episode "Tabula Rasa" as AMAZO's creator. Ivo worked for Lexcorp but was fired when Mercy Graves took over the company. When Lex Luthor went to see Ivo, he was already dead (contrary to the comics, where he was immortal) but Luthor found AMAZO instead.