In chemistry, prochiral molecules can be converted from achiral to chiral in a single step.

If two identical substituents are attached to an sp3-hybridized atom, the descriptors pro-R and pro-S are used to distinguish between the two. Promoting the pro-R substituent to higher priority than the identical alternative would result in an R chirality center at the original sp3-hybridized atom, and vice versa.

A trigonal planar sp2-hybridized atom can be converted to a chirality center when a substituent is added to the re or si face of the molecule.

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